Faculty
Candace Floyd, Ph.D.
Assistant Professor, Physical Med & Rehab
Faculty Detail Faculty Entry |
| Name: Candace Floyd, Ph.D. |
| Rank: Assistant Professor |
| Campus Address: SRC 547 |
| Phone: 996-6891 |
| E-mail: clfloyd@uab.edu |
| URL: |
| Department Affiliation(s) |
| Primary: Physical Medicine & Rehabilitation |
| Secondary: Neurobiology |
| Biographical Sketch |
| James Madison University, B.A. 1991 Virginia Commonwealth University, M.S. 1998 Virginia Commonwealth University, Ph.D. 2000 University of California, Davis Post-doc 2001-2004 A. Positions, Memberships, and Honors Faculty Positions: 2004- 2006 Assistant Professor, Department of Neurosurgery, University of California, Davis. 2006- present Assistant Professor, Department of Physical Medicine and Rehabilitation, Center for Glial Biology in Medicine, University of Alabama at Birmingham. Awards and Honors: 1997 Honorary Oral Presentation at 15th Annual Meeting of National Neurotrauma Society 1998 Honorary Oral Presentation at 16th Annual Meeting of National Neurotrauma Society 1999 Outstanding (1st place) paper and oral presentation in 27th Annual J. C. Forbes Graduate Student Honors Colloquium 1999 First Place in Medical Sciences Division of Student Competition at 77th Annual Virginia Academy of Science Meeting 1999 First Place in grant proposal competition which occurred at the First Annual Route 28 Summit in Neurobiology 1999 Finalist in student poster competition at the 17th Annual Meeting of National Neurotrauma Society 2000 Lauren A. Woods Award for Excellence Among Doctoral Students, MCV/VCU Department of Pharmacology/Toxicology 2003 Selected as poster presenter at the 2003 Spring Gordon Conference on Glial Biology 2005 Selected as poster presenter at the 2005 Spring Gordon Conference on Glial Biology 2005 Selected as “Emerging Topic” presenter at 11th International Symposium of Neuronal Regeneration B. Publications (in chronological order): Book Chapters: Hamm, R.J. Temple, M.D., Buck, D.L., DeFord, S.M, Floyd, C.L. (1998) Cognitive recovery from traumatic brain injury: Results of post-traumatic experimental interventions. In H.S. Levin and J. Grafman (eds.) Neuroplasticity and Reorganization of Function After Brain Injury. Oxford University Press. Floyd C.L. and Lyeth B.G. (in press) Astroglia: Moderators of CNS Injury. In J.T. Weber and A.M. Maas (eds.) Brain Injury. Elviser Press. Articles: Rice, A.C., Floyd, C.L., Lyeth, B.G., Hamm, R.J., and DeLorenzo, R.J. (1998) Chronic behavioral changes and cognitive deficits following pilocarpine induced status epilepticus (SE) occur early and are prevented by NMDA receptor inhibition during SE. Epilepsia 39 (11): 1148-1157. Floyd, C.L., Rzigalinski, B.A., Sitterding, H.A., Willoughby, K.A., and Ellis, E.F. (2001) Traumatic Injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling. Glia, 33 (1):12-23. Floyd, C.L., Golden, K.M., Black, R.T., Hamm, R.J., and Lyeth, B.G. (2002). Craniectomy position affects Morris water maze performance and hippocampal cell loss following parasagittal fluid percussion. Journal of Neurotrauma, 19 (3): 303-316. Rismanchi N, Floyd C.L., Berman, R.F., Lyeth, B.G. (2003). Cell death and long-term maintenance of neuron-like state after differentiation of rat bone marrow stromal cells: a comparison of protocols. Brain Research 991 (1-2): 46-55. Floyd, C.L. Rzigalinski, B.A. Sitterding, H.A., Wiloughby, K.A., and Ellis, E.F. (2004) Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes. Journal of Neurotrauma 21(2): 205-216) Hallam, T.M., Floyd, C.L., Folkarts, M.M., Lee, L., Lyeth, B.G., Berman, R.F. (2004) Comparison of behavioral deficits and acute neuronal degeneration in rat lateral fluid percussion and weight drop brain injury models. Journal of Neurotrauma. 21 (5):521-539. |
| Society Memberships | Current Position | URL | |
| National Neurotrauma Society | http://www.edc.gsph.pitt.edu/neurotrauma/index.html | ||
| International Neurotrauma Socitey | |||
| Society for Neuroscience | http://www.sfn.org/ | ||
| American Association for the Advancement of Science | http://www.aaas.org/ |
| Research/Clinical Interest Title |
| Pathobiology of Traumatic Brain and Spinal Cord Injury |
| Research/Clinical Interest Description |
| Millions of people a year suffer a traumatic brain or spinal cord injury (TBI or SCI); and in the blink of an eye, their lives may be changed forever. The current clinical repertoire for treating CNS injury is extremely limited. In fact, there are no pharmacological interventions to treat TBI and only one drug with questionable efficacy for use in SCI. Most previous research in CNS injury has focused on neuroprotection, and has discounted the role of glial cells in injury pathology. The central hypothesis of our research is that understanding of the complex interaction of glial and neuronal cells in the pathophysiology of traumatic CNS injury will lead to novel, effective therapeutic interventions. On-going projects include: a) estrogens, phytoestrogens, and selective estrogen receptor modulators (SERMs) as potential protective agents in SCI b) evaluation of fusion proteins for delivery of anti-apoptotic Bcl family proteins in SCI c) autophagy as a potential novel target in traumatic brain injury d) mechanisms of glial cell death in traumatic brain and spinal cord injury |
| Postdoc Positions Available |
| No positions available at this time |
| Selected Publications 0 | PubMed ID | |
| No records | ||
| First Prev 1 of 1 Next Last | ||
| Keywords |
| SCI, TBI, rat, mouse, astrocyte, protection, neuroprotection |
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